ABSTRACT
New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. These phenolic acid esters gave various degrees of free radical scavenging, but the values were lower than that of alpha-tocopherol. The concentrations of the tested compounds needed to reduce DPPH absorption by 50% at 517 nm were nearly in the range of 900-1100 micro g/mL. While for alpha-tocopherol was 40 micro g /mL. The compounds were tested in-vitro against six bacterial species which are known to cause dermic and mucosal infections in human. 2-phenoxyethyl benzoate showed significant activity in the range of 30% against P. aeruginosa to 70% against E. coli compared with the activity of Streptomycin. On the other hand 2-phenoxyethyl 2-hydroxybenzoate reveals 70% of gentamicin against K. pneumoniae. The tested compounds also showed complete inhibition at a concentration less than 37.5 micro g/mL against M. canis and less than 50 micro g/mL against T. rubrum. 2-phenoxyethyl 4-hydroxybenzoate showed considerable activity against MCF-7 with IC[50] is less than 62.5 micro g/mL
ABSTRACT
Accurate platelets count has an important role in the diagnosis of many haematological disorders such as thrombocytopenia, thrombocytosis as well as for prophylactic platelets transfusion. Therefore, it is necessary to select the most reliable method for such use. These methods include haemocytometry [Manual 1% ammonium oxalate technique], assessment of platelets from well prepared and stained thin blood film and automated analyzer system using KX-21 counter [Sysmex]. Out of 100 blood samples recruited for the study, 31 showed low platelets count, 61 showed normal platelets level and only 8 blood sample showed high platelets concentration. Result showed that the numbers of platelets counted by automated machine were significantly lower than that obtained by both manual methods in samples with less than 150000 platelets/micro L and more than 450000 platelets/micro L. Among normal blood samples, platelets count between 150000 and 450000 platelets/micro L no significant statistical difference detected between the counts obtained by the three techniques. It was concluded that automated blood analyzer systems, which have worldwide distribution, may have problems distinguishing large platelets, or aggregates from other blood cells. The assessment of platelets number using automated counters can reveal the accurate status in samples with normal platelet levels whereas it could not replace the manual ammonium oxalate method particularly in persons with high or low platelets count
Subject(s)
Humans , Clinical Laboratory Techniques , Cross-Sectional StudiesABSTRACT
Acute adrenocortical insufficiency [Addisonian crisis] is an emergency caused by insufficient cortisol and can manifest as a defect anywhere in the hypothalamic-pituitary-adrenal axis. It may be misdiagnosed as acute renal dysfunction due to similar clinical manifestations and laboratory findings. The causes, clinical features and management of Addison's disease are discussed in this review
Subject(s)
Humans , Male , Review , Hydrocortisone , Polyendocrinopathies, AutoimmuneABSTRACT
Fifty-nine years old Sudanese woman from Aldamazeen-Southern Blue Nile region of the Sudan, died 2 months after she had been diagnosed histopathologically as a case of a primary clear cell carcinoma of the gallbladder. Gallbladder cancer is a relatively rare form of malignancy. As yet, the progress in its management is very slow, which leads to high mortality and very low survival. At present, the best chances for this disease are early radical surgery but, in patients with invasion of adjacent organs, extended surgery, excising the invaded tissue, may be justified. In patients with distant lymph-node metastasis, even without adjacent organ invasion, radical surgery may not achieve a good outcome